基本情況
陳國(guó)棟，研究員，博士生導(dǎo)師，入選廣東省教育廳珠江學(xué)者特聘教授、廣東省自然科學(xué)基金杰出青年、廣州市珠江科技新星，長(zhǎng)期以中藥及植物內(nèi)生真菌作為研究對(duì)象，開(kāi)展中藥物質(zhì)基礎(chǔ)、候選藥物分子發(fā)現(xiàn)以及污染中藥材真菌毒素研究。
目前以第一/共同第一或共同通訊作者身份發(fā)表SCI論文39篇，包括Nat Comm、Acta Pharm Sin B、Org Lett、Chem Comm 等top期刊8篇，申請(qǐng)授權(quán)發(fā)明專(zhuān)利13個(gè)，其中3個(gè)為國(guó)外專(zhuān)利?，F(xiàn)擔(dān)任廣東省藥學(xué)學(xué)會(huì)藥物手性專(zhuān)業(yè)委員會(huì)副主任委員、中國(guó)菌物學(xué)會(huì)菌物化學(xué)專(zhuān)委會(huì)委員以及《Chinese Chemical Letters》青年編委會(huì)委員。同時(shí)不斷落實(shí)教書(shū)育人立德樹(shù)人根本任務(wù)，主持項(xiàng)1項(xiàng)廣東省高等教育教學(xué)改革項(xiàng)目并在擔(dān)任教工黨支部書(shū)記期間，以“一核心兩強(qiáng)化三融合”開(kāi)展“錘煉黨性，涵養(yǎng)師德”黨建工作，入選教育部首屆全國(guó)高?！半p帶頭人”教師黨支部書(shū)記工作室、教育部全國(guó)黨建工作樣板支部和廣東省黨建工作樣板支部。
聯(lián)系方式
地址：廣東省江門(mén)市蓬江區(qū)東成村22號(hào) 五邑大學(xué)藥學(xué)與食品工程學(xué)院
郵編：529020
郵箱：[email protected]
近五年主持的科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上基金項(xiàng)目(81973213) “基于活潑中間體驅(qū)動(dòng)策略的苔色酸二聚體多樣庫(kù)構(gòu)建及其神經(jīng)保護(hù)的構(gòu)效和機(jī)制研究” (2020-2023，56萬(wàn)元，在研)。
2. 國(guó)家自然科學(xué)基金面上基金項(xiàng)目(81673315) “基于多靶點(diǎn)抗阿爾茨海默癥的多節(jié)孢綠膠霉素類(lèi)化合物的優(yōu)選與作用機(jī)制研究” (2017-2020，52萬(wàn)元，在研)。
3. 國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2018YFC0311003) “海洋微生物候選藥物的高效發(fā)現(xiàn)與創(chuàng)制”項(xiàng)目子課題 (2018-2021，27.8萬(wàn)元，在研)。
4. 廣東省自然科學(xué)杰出青年基金項(xiàng)目(2017A03036027) “地衣內(nèi)生真菌中抗老年癡呆活性成分的發(fā)現(xiàn)及其作用機(jī)制研究” (2017-2021, 100萬(wàn)元，在研)。
廣州市珠江科技新星項(xiàng)目(201610010021) “地衣內(nèi)生真菌中抗AD活性成分研究” (2016-2019, 30萬(wàn)元，結(jié)題)。
近五年發(fā)表代表性論文
[1] Huang Hui-Yun, Huang Jia-Hua, Wang Yong-Heng, Hu Dan, Lu Yong-Jun, She Zhi-Gang, Chen Guo-Dong*, Yao Xin-Sheng, Gao Hao*. The oxidation cascade of a rare multifunctional P450 enzyme involved in asperterpenoid A biosynthesis. Frontiers in Chemistry, 2021, 9, 785431.
[2] Zhao Huan, § Zou Jian, § Xu Wei, Hu Dan, Guo Liang-Dong, Chen Jia-Xu, Chen Guo-Dong,* So Kwok-Fai, Yao Xin-Sheng, Gao Hao.* Diisoprenyl-cyclohexene/ane-type meroterpenoids from Biscogniauxia sp. and their anti-inflammatory activities. Journal of Organic Chemistry, 2021, 86, 11177-11188.
[3] Chen Guo-Dong,§ Zhao Bing-Xin,§ Huang Mei-Juan, Tang Jia, Li Yan-Bing, Guo Liang-Dong, He Rong-Rong, Hu Dan,* Yao Xin-Sheng, Gao Hao.* Tripodalsporormielones A–C, unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems. Acta Pharmaceutica Sinica B, 2021, 11, 3648-3654.
[4] Tian Dan-Mei, Cao Ling-Yun, Li Qing-Wen, Huang Hui-Yun, Xu Wei, Chen Guo-Dong*, Song Zhao-Hui, He Yi, Yao Xin-Sheng, Tang Jin-Shan*. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica pubescens. Bioorganic Chemistry, 2021, 107, 104604.
[5] Chen Guo-Dong, Hu Dan, Gao Hao, Yao Xin-Sheng*. The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry. Chinese Journal of Natural Medicines, 2020, 18, 241-242.
[6] Chen Guo-Dong§, Hu Dan§, Huang Mei-Juan§, Tang Jia, Wang Xiao-Xia, Zou Jian, Xie Jun, Zhang Wei-Guang, Guo Liang-Dong, Yao Xin-Sheng*, Abe Ikuro*, Gao Hao*. Sporormielones A–E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin. Chemical Communications, 2020, 56, 4607-4610. (§co-first author)
[7] Chen Guo-Dong, Wang Chuan-Xi, Hu Dan, Gao Hao, Yao Xin-Sheng*. Discovery of new metabolites from fungi in special habits and their biological function evaluations. Toxicon, 2019, 158, S29-S29.
[8] Zou Jian§, Chen Guo-Dong§, Zhao Huan, Wang Xiao-Xia, Zhang Zai-Jun, Qu Yi-Bo, He Rong-Rong, So Kwok-Fai, Yao Xin-Sheng, Gao Hao*. Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism. Chemical Communications, 2019, 55, 6221-6224. (§co-first author)
[9] Zhao Huan§, Wang Mei-Zhi§, Chen Guo-Dong*, Hu Dan, Li En-Qing, Qu Yi-Bo, Zhou Li-Bing, Guo Liang-Dong, Yao Xin-Sheng, Gao Hao*. Dimericbiscognienynes B and C: new diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp. Chinese Chemical Letters, 2019, 30, 51-54.
[10] Wang Gao-Qian§, Chen Guo-Dong§, Qin Sheng-Ying§, Hu Dan*, Awakawa Takayoshi, Li Shao-Yang, Lv Jian-Ming, Wang Chuan-Xi, Abe Ikuro*, Gao Hao*. Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage. Nature Communications, 2018, 9, 1838 (§co-first author)
[11] Zou Jian§, Chen Guo-Dong§, Zhao Huan, Huang Ying, Luo Xiang, Xu Wei, He Rong-Rong, Hu Dan, Yao Xin-Sheng, Gao Hao*. Triligustilides A and B: Two pairs of phthalide trimers from Angelica sinensis with a complex polycyclic skeleton and their activities. Organic Letters, 2018, 20, 884-887 (§co-first author)
[12] Li Jiao-Jiao§, Chen Guo-Dong§, Fan Hong-Xia, Hu Dan, Zhou Zheng-Qun, Lan Kang-Hua, Zhang Hui-Ping, Maeda Hideaki, Yao Xing-Sheng, Gao Hao*. Houttuynoid M, an anti-HSV active houttuynoid from Houttuynia cordata featuring a bis-houttuynin chain tethered to a flavonoid core. Journal of Natural Products, 2017, 80, 3010-3013 (§co-first author)
[13] Zhao Huan§, Chen Guo-Dong§, Zou Jian, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Li Guo-Qiang, Guo Liang-Dong, Yao Xin-Sheng*, Gao Hao*. Dimericbiscognienyne A: A meroterpenoid dimer from Biscogniauxia sp. with new skeleton and its activity. Organic Letters, 2017, 19, 38-41 (§co-first author)
[14] Sun Tian-Yu, Zou Jian, Chen Guo-Dong*, Hu Dan, Wu Bin, Liu Xing-Zhong, Yao Xin-Sheng, Gao Hao*. A set of interesting sequoiatone stereoisomers from a wetland soil-derived fungus Talaromyces flavus. Acta Pharmaceutica Sinica B, 2017, 7, 167-172.
[15] Wang Chuan-Xi§, Chen Guo-Dong§, Feng Chun-Chi, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Chen He-Ru, Liu Xing-Zhong, Yao Xin-Sheng*, Gao, Hao*. Same data, different structures: diastereoisomers with substantially identical NMR data from nature. Chemical Communications, 2016, 52, 1250-1253 (§co-first author)
申請(qǐng)專(zhuān)利
[1] 姚新生，洪葵，李佳，高昊，唐金山，林海鵬，高立信，陳國(guó)棟，謝晴宜，盛麗. 一種芳香類(lèi)化合物作為制備Caspase 3 抑制劑的用途. (ZL 201010230402.2)
[2] 高昊，姚新生，鄭易之，郭良棟，陳國(guó)棟，孫翔，鄭啟昌，孔明珠，李小霞. 脫甲綠膠酶素在制備β-淀粉樣蛋白聚集抑制劑中的用途. (201310196180.0)
[3] 高昊，姚新生，鄭易之，陳國(guó)棟，郭良棟，孫翔，趙歡，李小霞，孔明珠. 聯(lián)苯醚類(lèi)化合物在制備β-淀粉樣蛋白聚集抑制劑中的用途. (ZL201410332005.4)
[4] 高昊，陳國(guó)棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 裂環(huán)多節(jié)孢綠膠霉素類(lèi)化合物及其用途. (ZL201510111322.8)
[5] 高昊，陳國(guó)棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 多節(jié)孢綠膠霉素E及其用途. (ZL 201510112075.3)
[6] 高昊，陳國(guó)棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 多節(jié)孢綠膠霉素類(lèi)化合物及其用途. (ZL 201510112090.8)
[7] 高昊，陳國(guó)棟，姚新生，趙歡，郭良棟，胡丹，王傳喜，秦盛瑩，鄒劍. 二聚炭皮烯炔A及其在制備預(yù)防和治療神經(jīng)退行性疾病藥物中的應(yīng)用. (ZL201611101694.3)
[8] 高昊，陳國(guó)棟，姚新生，趙歡，郭良棟，胡丹，王傳喜，秦盛瑩，鄒劍. 炭皮酸A及其在制備預(yù)防和治療神經(jīng)退行性疾病藥物中的應(yīng)用. (ZL201611101594.0)
[9] 高昊，姚新生，何蓉蓉，李藥蘭，陳國(guó)棟，周正群，王傳喜，李滿(mǎn)妹，胡丹，范紅霞. 一種二咖啡酰亞精胺衍生物糖苷及其用途. (ZL201610032769.0、PCT/CN2017/071119)
[10] 高昊，姚新生，何蓉蓉，陳國(guó)棟，周正群，王傳喜，胡丹，范紅霞. 一種二咖啡酰亞精胺環(huán)化衍生物及其用途. (ZL201610033609.8、PCT/CN2017/071116)
[11] 高昊，胡丹，陳國(guó)棟，姚新生，秦盛瑩，王高乾，呂建明，李韶陽(yáng). 甾體化合物側(cè)鏈修飾基因及其應(yīng)用. (ZL201810335957.X)
[12] 陳國(guó)棟、趙歡、胡丹、王傳喜、代萍、劉妍穎、高昊、姚新生. 一種炭皮苯酞類(lèi)化合物、組合物、制備方法及其用途. (ZL 201910418547.6)
[13] 胡丹、韓雪、王傳喜、高昊、姚新生、陳國(guó)棟、代萍、張潔. 一種吲哚二萜生物堿類(lèi)化合物、組合物及其制備方法和用途. (ZL 201910495789.5)
[14] 高昊、陳國(guó)棟、姚新生、胡丹、代萍、唐佳、黃美娟.莢孢腔酮類(lèi)化合物及其制備方法和用途. (ZL202010165727.0)
[15] 陳國(guó)棟、高昊、胡丹、姚新生、代萍、黃美娟. 三橋環(huán)莢孢腔酮類(lèi)化合物及其制備方法和用途. (202110390198.9)
