基本情況
陳文華，博士，藥學(xué)與食品工程學(xué)院教授，博士生導(dǎo)師，現(xiàn)任五邑大學(xué)副校長(zhǎng)、五邑大學(xué)科協(xié)主席等職。兼任廣東省藥學(xué)會(huì)藥物化學(xué)專(zhuān)業(yè)委員會(huì)副主任委員和廣東省藥理學(xué)會(huì)理事等。曾留學(xué)日本和美國(guó)。研究領(lǐng)域?yàn)樗幬锘瘜W(xué)生物學(xué)，多年來(lái)專(zhuān)注于創(chuàng)新藥物的設(shè)計(jì)合成及生物活性機(jī)制研究。先后主持國(guó)家自然科學(xué)基金面上項(xiàng)目等10余項(xiàng)科研項(xiàng)目，在J. Am. Chem. Soc., J. Med. Chem.等頂尖學(xué)術(shù)刊物上發(fā)表SCI論文160余篇，獲授權(quán)發(fā)明專(zhuān)利10余件。2016年獲日本兵庫(kù)震災(zāi)紀(jì)念21世紀(jì)研究機(jī)構(gòu)兵庫(kù)海外研究網(wǎng)絡(luò)（Hyogo Overseas Research Network）事業(yè)推進(jìn)獎(jiǎng)。入選全球前2%頂尖科學(xué)家榜單“終生科學(xué)影響力排行榜”科研人員。
聯(lián)系方式
地址: 廣東江門(mén)市東成村22號(hào) 五邑大學(xué) 藥學(xué)與食品工程學(xué)院，郵編529020
E-mail: [email protected]
教育經(jīng)歷
1994年 四川大學(xué)化學(xué)系 化學(xué)專(zhuān)業(yè)學(xué)士學(xué)位
2000年 日本長(zhǎng)崎大學(xué)藥學(xué)院 藥物化學(xué)專(zhuān)業(yè)博士學(xué)位
工作經(jīng)歷
2000年4月-2002年3月，日本科學(xué)技術(shù)振興機(jī)構(gòu) 博士研究員
2002年4月-2005年10月，中山大學(xué)化學(xué)與化學(xué)工程學(xué)院 副教授
2004年7月-2009年8月，美國(guó)里海大學(xué)化學(xué)系 研究科學(xué)家
2009年8月-2018年12月，南方醫(yī)科大學(xué)藥學(xué)院 教授，博士生導(dǎo)師
2019年1月-2023年11月，五邑大學(xué)生物科技與大健康學(xué)院 教授，博士生導(dǎo)師
2023年11月-至今，五邑大學(xué)藥學(xué)與食品工程學(xué)院 教授，博士生導(dǎo)師
講授課程
本科生：《藥物化學(xué)》《實(shí)驗(yàn)藥物化學(xué)》《高等藥物化學(xué)》《有機(jī)結(jié)構(gòu)解析》
研究生：《有機(jī)波譜分析》
科研方向
1) 基于離子跨膜轉(zhuǎn)運(yùn)機(jī)制的抗腫瘤藥物的設(shè)計(jì)合成及生物活性
2) 生物重要分子的生物傳感器的構(gòu)筑
科研項(xiàng)目
1) 國(guó)家自然科學(xué)基金面上項(xiàng)目，氟代陰離子轉(zhuǎn)運(yùn)體的合成及其誘導(dǎo)細(xì)胞死亡機(jī)制研究，63萬(wàn)元，2019年01月-2022年12月，主持。
2) 江門(mén)市科學(xué)技術(shù)局創(chuàng)新科研團(tuán)隊(duì)引進(jìn)資助項(xiàng)目(新生物功能分子的發(fā)現(xiàn)與開(kāi)發(fā)研究創(chuàng)新團(tuán)隊(duì))，嶺南15種藥食同源植物活性物質(zhì)基礎(chǔ)和深度開(kāi)發(fā)研究，600萬(wàn)，2019年01月-2021年12月，第二核心成員。
近五年發(fā)表的主要論文
(1) Yufei Zhang , Jingjing Liu , Jiangyi Li , Jinping Sun , Bingwen Liang , Xiaofeng Min , Zhuang Xiong*, Wen-Hua Chen*, Xuetao Xu*, Design, synthesis and biological evaluation of a 1,2,3-triazolyl-bearing betulinic acid derivatives as α-glucosidase inhibitors, J. Mol. Struct., 2025, 1328, 141252.
(2) Wantao Liao, Chunzheng Wang, Ruiya Wang, Mengzhao Wu, Lanqing Li*, Pengjie Chao, Jinhui Hu, Wen-Hua Chen*, An activatable “AIE + ESIPT” fluorescent probe for dual-imaging of lipid droplets and hydrogen peroxide in drug-induced liver injury model, Anal. Chim. Acta, 2025, 1335, 343442
(3) Jingxin Hu, Ruiya Wang, Wantao Liao, Jinhui Hu, Langing Li*, Zhen Cheng*, Wen-Hua Chen*, A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide. Anal. Chim. Acta, 2024, 1296, 342333.
(4) Xiang Qiu, Yanghui Ou, Shengjia Lu, Yibin Liang, Yali Zhang, Mengjie Li, Gang Li, Hongwei Ma, Yanting Wu, Zhaoyu He, Zhensheng Zhang, Hongliang Yao*, Wen-Hua Chen*, Study on the structure and bioactivity of polysaccharides from different parts of Stemona tuberosa Lour, Molecules, 2024, 29, 1347.
(5) Yufei Zhang, Jiangyi Li, Xiaofeng Min, Bingwen Liang, Jinping Sun, Keyin Lin, Zhuang Xiong*, Xuetao Xu*, Wen-Hua Chen*, 1,2,3-Triazole-based betulinic acid derivatives as α-glucosidase inhibitors: Synthesis and in vitro and in vivo biological evaluation. J. Mol. Struct., 2024, 1310, 138294.
(6) Yufei Zhang, Xiaoyan Yu, Jiangyi Li, Bingwen Liang, Jinping Sun, Xiaofeng Min, Zhuang Xiong*, Wen-Hua Chen*, Xuetao Xu*, Design, synthesis and biological evaluation of novel betulinic acid derivatives containing 1,2,4-triazole-derived schiff bases as α-glucosidase inhibitors. J. Mol. Struct., 2024, 1315, 138889.
(7) Yuechang Huang#, Xingmin Zhang#, Qian Li, Wende Zheng, Panpan Wu, Rihui Wu*, Wen-Hua Chen*, Chen Li*, N-p-Coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3? pathway, Front. Pharmacol., 2024, 15, 1396641.
(8) Hai-Tao Zhi, Zhonghui Lu, Li Chen, Jia-Qiang Wu, Lanqing Li, Jinhui Hu*, Wen-Hua Chen*, Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates, Bioorg. Chem., 2024, 147, 107421.
(9) Jifan Cao, Wende Zheng, Baizhong Chen, Zhenping Yan, Xiaowen Tang, Jiahao Li, Zhen Zhang, Song Ang, Chen Li, Rihui Wu, Panpan Wu*, Wen-Hua Chen*, Chemical composition of essential oil from Citrus reticulata Blanco cv. Chachiensis (Chachi) and its anti-mosquito activity against Pyrethroid-resistant Aedes albopictus. Insects, 2024, 15, 345.
(10) Zi Li#, Chengguo Li#, Baizhong Chen, Bing Li, Gang Huang, Yuhao Huang, Yajun Hou, Pengjun Zhong, Jingwei Jin, Dongli Li, Karl Wah Keung Tsim, Lishe Gan*, Wen-Hua Chen*, Rihui Wu*, Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway, Int. J. Biol. Macromol., 2024, 277, 133726.
(11) Lanqing Li*, Chunzheng Wang, Jinhui Hu*, Wen-Hua Chen*, Recent progresses in organelle-targeting fluorescent probes for the detection of peroxynitrite, Chem. Commun., 2024, 60, 13629 - 13640.
(12) Wei Lin, Yifei Qu, Huixuan Zhu, Mei Xie, Jinhui Hu, Zhuang Xiong, Wen-Hua Chen*, Jun Xu* and Jia-Qiang Wu*, Rh(III)-catalyzed, redox-neutral, C–H multifluoro- alkenylation of benzamides, Synthesis, 2024, 56, 3045 - 3053.
(13) Xiang Qiu#, Yan Geng#, Xiaoyue Cai, Yanghui Ou, Mengjie Li, Yali Zhang, Dengqin He, Xudong Qian, Yanting Wu, Hongwei Ma, Jing-Kun Yan*, Hongliang Yao* and Wen-Hua Chen*, Anti-inflammatory activity and underlying mechanism against sepsis-induced acute lung injury of a low-molecular-weight polysaccharide from the root of Stemona tuberosa Lour. Int. J. Biol. Macromol., 2024, 282, 136617.
(14) Yifei Qu#, Xiaojia Cai#, Yuzhuang Guan#, Jiamin Tan, Zhangping Cai, Minyun Liu, Yasi Huang, Jinhui Hu*, Wen-Hua Chen* and Jia-Qiang Wu*, Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines, Org. Biomol. Chem., 2023, 22, 90 - 94.
(15) Min Yuan, Jinhui Hu*, Wen-Hua Chen*, Synthesis of a Golgi-Targeting Fluorescent Probe for the Selective Detection of Chloride Anions, Org. Biomol. Chem., 2023, 21, 5732 - 5736.
(16) Li Chen, Yunfei Hu, Zhonghui Lu, Zeyin Lin, Lanqing Li, Jia-Qiang Wu, Zhi-Ling Yu, Chunye Wang, Wen-Hua Chen*, Jinhui Hu*, Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]Triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2, J. Med. Chem., 2023, 66, 15006 - 15024.
(17) Weiqiang Sun, Xueli Cui, Jing Qu, Xiaojia Cai, Jinhui Hu, Zhuang Xiong, Suqin Guo, Jun Xu*, Wen-Hua Chen*, Jia-Qiang Wu*, Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines, Chem. Commun., 2023, 59(47), 7228-7231.
(18) Xueli Cui, Jing Qu, Jianfeng Yi, Weiqiang Sun, Jinhui Hu, Suqin Guo, Jing-Wei Jin, Wen-Hua Chen*, Wing-Leung Wong*, Jia-Qiang Wu*, Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination, Chem. Commun., 2023, 59, 3747-3750.
(19) Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu*, Wen-Hua Chen*, Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity, Eur. J. Med. Chem., 2023, 261, 115795.
(20) Xiaojia Cai, Jinyuan Xu, Xueli Cui, Jing Qu, Weiqiang Sun, Jinhui Hu, Shuwen Zhao, Wen-Hua Chen*, Hongliang Li*, Jia-Qiang Wu*, Synthesis of di?uoromethyl carbinols from the Friedel-Crafts reaction of electron-rich arenes with di?uorovinyl arylsulfonates, Org. Chem. Front., 2022, 9, 6273 - 6280.
(21) Yunfei Hu, Li Chen, Canlin Zou, Jiangtao He, Luanqi Feng, Jia-Qiang Wu*, Wen-Hua Chen*, Jinhui Hu*, Access to 3-Amino-[1,2,4]-Triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization, Org. Lett., 2022, 24 (28), 5137 - 5142.
(22) Tao Zhang, Xiao-Qiao Hong, Hai-Tao Zhi, Jinhui Hu*, Wen-Hua Chen*, Synthesis and Mechanism of Biological Action of Morpholinyl-Bearing Arylsquaramides as Small-Molecule Lysosomal pH Modulators, RSC Adv., 2022, 12 (35), 22748 - 22759.
(23) Cheng-Jun Wu, Jia-Qiang Wu, Yunfei Hu, Suyun Pu, Yuying Lin, Zimai Zeng, Jinhui Hu*, Wen-Hua Chen*, Design, Synthesis and Biological Evaluation of Indole-based[1,2,4]Triazolo[4,3-a]Pyridine Derivatives as Novel Microtubule Polymerization Inhibitors, Eur. J. Med. Chem., 2021, 223, 113629.
